There is really no doubt that XKCD has had an impact on peoples’ lives. 100% of the reason I have a chess board with pieces glued to it is because of XKCD. I can only imagine how my career would have turned out if I read Randall Munroe’s recent post about every major being terrible.
Several people have put the comic to music.
Here is a Modern Major General version
And just for fun Tom Lehrer singing about the periodic table of elements